TRIFUNCTIONAL ANTIBODY-CYTOKINE FUSION PROTEIN FORMATS FOR TUMOR-TARGETED COMBINATION OF IL-15 WITH IL-7 OR IL-21

Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, Colored Pencils we investigated the molecular design of tumor-directed trifunctional antibody-cyt

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PCA-based sub-surface structure and defect analysis for germanium-on-nothing using nanoscale surface topography

Abstract Empty space in germanium (ESG) or germanium-on-nothing (GON) are unique self-assembled germanium structures with multiscale cavities of various morphologies.Due to their simple fabrication process and high-quality crystallinity after self-assembly, they can be applied in various fields including micro-/nanoelectronics, optoelectronics, and

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